The GMB presenter, 55, also went on to hit out at the pair "only wanting positive media coverage" and went on to compare them to dictators Kim Jong-Un and Vladimir Putin.
Today on Good Morning Britain, a clip of the Duke and Duchess of Sussex speaking to Oprah was aired, with Harry saying that he feared "history was repeating itself" prior to them leaving the UK.
Responding to the clip, Susanna Reid remarked: "It's quite remarkable, isn't it!"
Piers quickly went onto blast Harry for hitting out at the media coverage turning "toxic".
"They only want positive media coverage," Piers fumed, before comparing them to Kim Jong-Un and Vladimir Putin, leaving Susanna stunned.
Referencing Prince Harry's interview with James Corden last month, he continued: "Does it get any more embarrassing than this - being on an open top bus while banging on about press coverage?"
"They're dishing out left, right and centre," Piers said of the couple speaking about their experience in the royal family. "The whole thing is utterly ridiculous."
During the interview with Oprah, Prince Harry appeared to reference his mum, Princess Diana, saying: "I'm just really relieved and happy to be sitting here talking to you with my wife by my side.
"Because I can't imagine what it must have been like for her (Diana), going through this process by herself all those years ago.
"It's been unbelievably tough for the two of us, but at least we had each other."
Reacting to his comments, Piers fumed: "There is no comparison between the media attention Meghan got to Diana."
He added: "The hypocrisy is off the charts - 'Please leave us alone, but let us do open top bus interviews'."
